Synthesis of a novel chemotype via sequential metal-catalyzed cycloisomerizations
نویسندگان
چکیده
Sequential cycloisomerizations of diynyl o-benzaldehyde substrates to access novel polycyclic cyclopropanes are reported. The reaction sequence involves initial Cu(I)-mediated cycloisomerization/nucleophilic addition to an isochromene followed by diastereoselective Pt(II)-catalyzed enyne cycloisomerization.
منابع مشابه
Development of novel Lewis acid catalyzed cycloisomerizations: synthesis of bicyclo[3.1.0]hexenes and cyclopentenones
The Lewis acid catalyzed cyclization of hexatrienes and pentadienals to bicyclo[3.1.0]hexenes and cyclopentenones, respectively, was investigated. The application of the former reaction to the total synthesis of photodeoxytridachione, a molluscan polypropionate, is described. q 2003 Elsevier Ltd. All rights reserved.
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